GSK - Postdoctoral Associate
Basic qualifications:
• Ph.D. degree and/or a M.D./Ph.D. in immunology or related discipline.
• Demonstrated history of excellence in T-cell biology and/or cell and gene therapy.
• Experience in molecular biological techniques including cloning, viral based gene transfer (e.g. Lentivirus) into cell lines and primary immune cells, producing and manipulating lentiviral constructs and transduction techniques.
• Good knowledge and practical experience in cell culture techniques, multi-colour flow cytometry and immune based assay (e.g. cytokine release assays, cell surface marker analysis, intracellular flow cytometry, assessment of T-cell functionality).
• Ability to understand, interpret, and communicate complex scientific data to a range of audiences and must be comfortable conversing with opinion leaders regarding highly technical information.
• Self-motivated with an ability to handle multiple projects concurrently.
• Ability to trouble-shoot occurring problems and develop improved processes, with a good balance of creative and analytical skills.
• Strong communication skills.
• An ability to be productive and successful in an intense work environment.
• Ph.D. degree and/or a M.D./Ph.D. in immunology or related discipline.
• Demonstrated history of excellence in T-cell biology and/or cell and gene therapy.
• Experience in molecular biological techniques including cloning, viral based gene transfer (e.g. Lentivirus) into cell lines and primary immune cells, producing and manipulating lentiviral constructs and transduction techniques.
• Good knowledge and practical experience in cell culture techniques, multi-colour flow cytometry and immune based assay (e.g. cytokine release assays, cell surface marker analysis, intracellular flow cytometry, assessment of T-cell functionality).
• Ability to understand, interpret, and communicate complex scientific data to a range of audiences and must be comfortable conversing with opinion leaders regarding highly technical information.
• Self-motivated with an ability to handle multiple projects concurrently.
• Ability to trouble-shoot occurring problems and develop improved processes, with a good balance of creative and analytical skills.
• Strong communication skills.
• An ability to be productive and successful in an intense work environment.
Preferred qualifications:
• Experience of working in, or alongside, a Pharma or Biotech company would be an advantage.
• Basic and proven understanding of data quality.
• Experience in working with tumour infiltrating lymphocytes
• Experience in conducting animal work.
• Good knowledge of tumour biology.
• Experience of working in, or alongside, a Pharma or Biotech company would be an advantage.
• Basic and proven understanding of data quality.
• Experience in working with tumour infiltrating lymphocytes
• Experience in conducting animal work.
• Good knowledge of tumour biology.
Details: Post-doctoral fellows within GSK’s collaborative training programme will have opportunity to:
• Be part of cutting edge science to advance GSK’s mission ‘to improving the quality of human life by enabling people to do more, feel better, and live longer’.
• Accelerate your post-doctoral research with GSK’s extensive R&D engine.
• Bridge the gap from target identification to medicine for patients in-need.
By joining us for your post-doctoral training, you will be prepared for a career in industry, academia, or a regulatory organization as well as an opportunity to put yourself at the forefront of science.
Your Postdoctoral journey will be accompanied by tremendous support at GSK with the opportunity for daily collaborations with world-class scientists. GSK is committed to providing each postdoc with a mentor who will be a high-calibre scientist within our R&D community.
Postdocs are actively encouraged to present their research at internal and external meetings, and mentors are expected to nurture skills that will enable postdocs to become independent scientific investigators.
In 2014, GlaxoSmithKline has stepped up to become a leader in Cell and Gene Therapy . The newly formed platform research discovery group, in Stevenage, is supporting R&D Therapy Areas, collaborating with academic leaders and identifying and acquiring enabling technology platforms essential to meet GSK’s ambition in the field. This post-doctoral role is a collaboration between GSK platform research discovery group and the laboratory of Dr David Gilham within the Clinical and Experimental Immunotherapy group at the Institute of Cancer Sciences, University of Manchester.
We are looking for a post-doc with a strong background in fundamental and translational biology for a three years fix-term project related to chimeric antibody receptor T-cell (CAR-T) therapy of solid tumours. This project will be conducted at Manchester University.
The goals of the project is to:
• Generate Tumour Infiltrating Lymphocytes (TIL) and autologous cell lines using and refining state of the art extracting and expansion methodology.
• Deliver chimeric antibody receptor to Tumour Infiltrating Lymphocytes (TIL) or T-cells using Lentivirus.
• Conduct in vitro functional assessment and comparison of the CAR-T therapies using state of the art flow cytometry methodology and cell culture assays .
• With a positive outcome of the assessment, the aim is to conduct further investigation leading potentially to pre-clinical assessment.
The project goals are amenable to publication, yet linked to our aim to increase cell and gene therapy research platforms knowledge.
This is a three years fix-term position with a competitive salary.
Location at which the work will be conducted is the Institute of Cancer Sciences, Manchester University
Please use the cover letter to highlight how you fit the applicant profile and meet the skills and competencies for the role. Your cover letter along with your CV will be used to assess your application.
• Be part of cutting edge science to advance GSK’s mission ‘to improving the quality of human life by enabling people to do more, feel better, and live longer’.
• Accelerate your post-doctoral research with GSK’s extensive R&D engine.
• Bridge the gap from target identification to medicine for patients in-need.
By joining us for your post-doctoral training, you will be prepared for a career in industry, academia, or a regulatory organization as well as an opportunity to put yourself at the forefront of science.
Your Postdoctoral journey will be accompanied by tremendous support at GSK with the opportunity for daily collaborations with world-class scientists. GSK is committed to providing each postdoc with a mentor who will be a high-calibre scientist within our R&D community.
Postdocs are actively encouraged to present their research at internal and external meetings, and mentors are expected to nurture skills that will enable postdocs to become independent scientific investigators.
In 2014, GlaxoSmithKline has stepped up to become a leader in Cell and Gene Therapy . The newly formed platform research discovery group, in Stevenage, is supporting R&D Therapy Areas, collaborating with academic leaders and identifying and acquiring enabling technology platforms essential to meet GSK’s ambition in the field. This post-doctoral role is a collaboration between GSK platform research discovery group and the laboratory of Dr David Gilham within the Clinical and Experimental Immunotherapy group at the Institute of Cancer Sciences, University of Manchester.
We are looking for a post-doc with a strong background in fundamental and translational biology for a three years fix-term project related to chimeric antibody receptor T-cell (CAR-T) therapy of solid tumours. This project will be conducted at Manchester University.
The goals of the project is to:
• Generate Tumour Infiltrating Lymphocytes (TIL) and autologous cell lines using and refining state of the art extracting and expansion methodology.
• Deliver chimeric antibody receptor to Tumour Infiltrating Lymphocytes (TIL) or T-cells using Lentivirus.
• Conduct in vitro functional assessment and comparison of the CAR-T therapies using state of the art flow cytometry methodology and cell culture assays .
• With a positive outcome of the assessment, the aim is to conduct further investigation leading potentially to pre-clinical assessment.
The project goals are amenable to publication, yet linked to our aim to increase cell and gene therapy research platforms knowledge.
This is a three years fix-term position with a competitive salary.
Location at which the work will be conducted is the Institute of Cancer Sciences, Manchester University
Please use the cover letter to highlight how you fit the applicant profile and meet the skills and competencies for the role. Your cover letter along with your CV will be used to assess your application.
Please apply via the APPLY link below: https://careers.peopleclick.com/careerscp/client_gsk/external1931/gateway.do?functionName=viewFromLink&jobPostId=270891&localeCode=en-us
Closing date: 10th September 2015
Salary: £ Competitive
Location: Manchester
